Located at the Faculty of Liberal Arts,Ubon Ratchathani University the Mekong Sub-region Social Research Centre (MSSRC) was established in 2000 to support the Indochinese program for undergraduate students, the master degree program in Mekong regional studies and regional language courses including Chinese, Lao, Khmer and Vietnamese.

Situated at the centre of the Mekong River Basin in the northeastern region of Thailand the MSSRC facilitates and encourages research and learning about the Greater Mekong Sub-region (GMS), especially by regional scholars. The centre is dedicated to forging links between academics, researchers and students from universities and organisations within the region and beyond. It also promotes sharing knowledge across the region through activities that bolster the dissemination of information, such as an online database, informative website, teaching, publications, workshops, brown bag discussion group and conferences.

Since its inception the MSSRC has been involved in several projects that have sought to achieve these aims. In 2001 the centre organised a conference on Indochina in Transition . In 2002 the MSSRC brought together Thai scholars whose work focused on the Greater Mekong Sub-region from various Thai universities and institutions at the Mekong Studies Regional Consortium . The event facilitated discussion about the establishment of an academic consortium that would lead to collaboration on certain activities such as the Mekong curriculum and study program development and scholar exchange programs .

In 2003 the MSSRC became involved with the Regional Mekong Curriculum Development Initiative (RMCDI), now known as the Mekong Learning Initiative (MLI) which aims  to develop a regional and locally engaged approach to teaching about environment, natural resource management and rural social issues in order to foster a greater sense of Mekong citizenship' with regard to livelihood, development and environment questions in this shared river basin. The MLI is a collaboration between nine universities in five countries of the Mekong River Basin .

In September 2004 the MSSRC commenced a project entitled Strengthening of Knowledge and Information Sharing in the Greater Mekong Sub-region with support from the Rockefeller Foundation . The project involved the establishment of the Greater Mekong Sub-region Resource Centre (GMSRC), the centre enhanced the capacity of the GMSRC through the expansion of its collection and continued development of its database. However, the GMSRC is now closed.

The MSSRC continues sharing Makong knowledge and information which also saw the succesful organisation of the international conference and publications until now.